CELLULAR AND METABOLIC CHARACTERISTICS OF PRE-LEUKEMIC HEMATOPOIETIC PROGENITORS WITH GATA2 HAPLOINSUFFICIENCY

Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency

Mono-allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), affecting more than 85% of carriers.How a partial loss of GATA2 functionality enables leukemic transformation years later is unclear.This question has remained unsolved mainly due

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PENGARUH UMUR POHON, BONITA DAN POSISI AKSIAL BATANG TERHADAP STRUKTUR MAKROSKOPIS DAN KUALITAS KAYU JATI SEBAGAI BAHAN FURNITUR (Effect of Tree Age, Site Quality Index and Trunk Axial Position on Macroscopic Structure and Quality of Teak Wood)

ABSTRAK Penggunaan kayu jati muda merupakan solusi alternatif terhadap terbatasnya ketersediaan bahan baku yang dihadapi oleh industri mebel.Kayu muda cenderung memiliki kayu berkualitas rendah.Salah satu pengukur kualitas kayu adalah sifat struktur makroskopik.Penelitian bertujuan untuk mengetahui pengaruh umur pohon, bonita dan posisi aksial bata

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Depression of hepatic dolichol levels by cholesterol feeding.

A study was conducted to determine whether repression of 3-hydroxy-3-methylglutaryl CoA reductase by a chronic high-cholesterol diet would deplete hepatic dolichol Whip levels.Four-week-old male C57BL/6J mice were maintained on a control diet or a diet supplemented with 5% cholesterol.Animals from both groups were killed at various times and reduct

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